Tag: 500 dalton

The 500 Dalton Rule: Understanding Skin Penetration & Optimizing Your Skincare Routine

Mar 19, 2025

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by

thuychi2609

in Skincare Nerds

When it comes to skincare, not all ingredients penetrate the skin equally. Some stay on the surface, while others absorb deeply and deliver transformative effects. The 500 Dalton Rule explains which molecules can pass through the skin barrier and influence skin health. What Is the 500 Dalton Rule? The 500 Dalton Rule states that only…